(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide

Name	SRT-2183
Synonyms	SRT2183 SRT-2183 (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide 2-Naphthalenecarboxamide, N-[2-[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]-
CAS	1001908-89-9

Molecular Formula	C27H24N4O2S
Molar Mass	468.57
Storage Condition	-20℃
In vitro study	1-20 μm SRT2183 can effectively inhibit cell growth and apoptosis. It causes increased mRNA levels of genes associated with pro-apoptosis, growth arrest, and DNA damage responses. SRT1720, SRT2183, SRT1460 and resveratrol have multiple off-target effects on some receptors, enzymes, transporters and ion channels. They are not direct activators of SIRT1. SRT2183 had no or little effect on SIRT1 deacetylation activity. SRT2183 activates AMPK, increases the expression of Sirt1, reduces the acetylation level of lysine at 310 of RelA/p65, plays a key role in the activation of NF-κB, the establishment of Sirt1 target, and plays a key role in bone marrow macrophages, inhibits RANKL-induced osteoclastogenesis and resorption capacity.

biological activity	SRT2183 is a small molecule activator of the sirtuin protein subtype SIRT1.
Target	Value

Last Update：2024-04-10 22:29:15

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Product Name: SRT-2183 Visit Supplier Webpage Request for quotation
CAS: 1001908-89-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide Request for Quotation